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Human Protein Atlas tissue level rna expression profiles ntpm
Tissue Level Rna Expression Profiles Ntpm, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/expression+levels/distribution+human+level+protein+tissue+usp13/pm42276320-69-16-9
Average 86 stars, based on 1 article reviews
tissue level rna expression profiles ntpm - by Bioz Stars, 2026-10
86/100 stars

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Related Articles

Gene Expression:

Article Title: TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury.
Article Snippet: Ischemia-reperfusion injury refers to the damage that occurs in an organ or tissue following the restoration of blood supply after a period of ischemia.. Intestinal ischemia-reperfusion injury (I/R) represents a worldwide public health issue characterized by excessive inflammation and currently lacks effective clinical therapies.. Activation of the NLRP3 inflammasome is not only a hallmark feature of intestinal I/R but also serves as a significant exacerbating factor in intestinal deterioration.

Expressing:

Article Title: TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury.
Article Snippet: Ischemia-reperfusion injury refers to the damage that occurs in an organ or tissue following the restoration of blood supply after a period of ischemia.. Intestinal ischemia-reperfusion injury (I/R) represents a worldwide public health issue characterized by excessive inflammation and currently lacks effective clinical therapies.. Activation of the NLRP3 inflammasome is not only a hallmark feature of intestinal I/R but also serves as a significant exacerbating factor in intestinal deterioration.

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Article Title: Exploring the Role of GGA2 in Cancer Progression: Pan-Cancer Bioinformatics and Experimental Validation in Prostate Cancer
Article Snippet: .. GGA2 protein levels were analyzed through immunohistochemistry based on the HPA (Human Protein Atlas) database, with results showing significantly lower expression in 10 cancer types and higher in 4 compared to normal tissues ( ). ..

Article Title: Pan-cancer analysis and experimental validation identify CYP19A1 as a prognostic biomarker and oncogenic driver associated with tumor immune microenvironment regulation in gastrointestinal cancers.
Article Snippet: .. RNA and Protein Expression Analysis A comprehensive study of RNA expression levels, measured as normalized Transcripts Per Million (nTPM) for cross-tissue expression level comparison, and protein expression levels across different human organs and tissues was performed using data from the Human Protein Atlas (HPA)11. ..

Article Title: Sugen kinase 495 promotes the proliferation, migration and invasion of lung squamous cell carcinoma cells by targeting Foxo1 transcription factor.
Article Snippet: .. Figure legends AR TIC LE IN PR ES S Fig. 1 Sgk495 is highly expressed in LUSC and associated with poor prognosis. (A) Representative immunohistochemical images of Sgk495 protein expression in human lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) clinical tissue samples, obtained from the Human Protein Atlas (HPA) database. (B) Disease-free survival (DFS) analysis of LUSC patients from the TCGA database, stratified by high and low Sgk495 mRNA expression levels. ..

Article Title: Recognition of immunogenomic signature and prognostic value of the subtype of epithelial-mesenchymal transition in breast cancer
Article Snippet: .. The protein expression levels of EMT signature genes are displayed in the Human Protein Atlas (HPA) database ( https://www.proteinatlas.org/ ), which covers the distribution and expression information of over 24000 proteins in normal human and tumor tissues. ..

Article Title: TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson’s disease
Article Snippet: .. Using data on TMBIM6 mRNA expression levels from The Human Protein Atlas database (THPA) [ ], we confirmed through in silico analysis that TMBIM6 is expressed in various cortical regions of the human brain, with notably high expression in the midbrain and retina, two areas rich in DAergic cells [ , ] (Fig. ). ..

RNA Sequencing:

Article Title: Multi-Omics Analysis of CDKN2A (p16INK4a) in Cervical Carcinoma in the Context of Human Papillomavirus and in Endometrial Carcinoma
Article Snippet: .. To further validate CDKN2A transcript levels across various malignancies, RNA sequencing data from the TCGA dataset integrated in the Human Protein Atlas (HPA) were analyzed ( ). ..

Activation Assay:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

MTT Assay:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Western Blot:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Phospho-proteomics:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Activity Assay:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Biomarker Discovery:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Knockdown:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Real-time Polymerase Chain Reaction:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Inhibition:

Article Title: Stattic enhances the anti-tumor activity of AZD4547 in LUSC by blocking STAT3/RRM2-mediated DNA repair and inducing ROS-driven mitochondrial dysfunction.
Article Snippet: .. AZD4547 inhibits FGFR signaling but induces compensatory activation of the IL-6/STAT3 axis in lung squamous cell carcinoma cells. (A) Schematic illustration showing that AZD4547 functions as a selective FGFR inhibitor. (B) FGFR expression levels in lung squamous cell carcinoma cell lines (H520 and H1703) and the non-malignant bronchial epithelial cell line BEAS-2B, based on data from the Human Protein Atlas. (C, D) MTT and colony-formation assays showing that AZD4547 suppresses the proliferation of H520 and H1703 cells in a dose-dependent manner, whereas BEAS-2B cells exhibit relative resistance to AZD4547 treatment. (E) Western blot analysis of STAT3 phosphorylation and PI3K/AKT and MEK/ERK pathway activity following AZD4547 treatment. (F, G) Validation of STAT3 knockdown efficiency in lung squamous cell carcinoma cells by Western blotting and quantitative PCR. (H) Effects of STAT3 knockdown on AZD4547mediated growth inhibition in lung squamous cell carcinoma cells. (I, J) Western blotting and quantitative PCR analyses showing upregulation of IL-6 expression upon AZD4547 treatment. (K-M) Effects of IL-6 knockdown on STAT3 phosphorylation, as determined by Western blotting and quantitative PCR. (N) Effects of IL-6 knockdown on the cytotoxic activity of AZD4547 in lung squamous cell carcinoma cells. ..

Immunohistochemistry:

Article Title: Exploring the Role of GGA2 in Cancer Progression: Pan-Cancer Bioinformatics and Experimental Validation in Prostate Cancer
Article Snippet: .. GGA2 protein levels were analyzed through immunohistochemistry based on the HPA (Human Protein Atlas) database, with results showing significantly lower expression in 10 cancer types and higher in 4 compared to normal tissues ( ). ..

RNA Expression:

Article Title: Pan-cancer analysis and experimental validation identify CYP19A1 as a prognostic biomarker and oncogenic driver associated with tumor immune microenvironment regulation in gastrointestinal cancers.
Article Snippet: .. RNA and Protein Expression Analysis A comprehensive study of RNA expression levels, measured as normalized Transcripts Per Million (nTPM) for cross-tissue expression level comparison, and protein expression levels across different human organs and tissues was performed using data from the Human Protein Atlas (HPA)11. ..

Comparison:

Article Title: Pan-cancer analysis and experimental validation identify CYP19A1 as a prognostic biomarker and oncogenic driver associated with tumor immune microenvironment regulation in gastrointestinal cancers.
Article Snippet: .. RNA and Protein Expression Analysis A comprehensive study of RNA expression levels, measured as normalized Transcripts Per Million (nTPM) for cross-tissue expression level comparison, and protein expression levels across different human organs and tissues was performed using data from the Human Protein Atlas (HPA)11. ..

Immunohistochemical staining:

Article Title: Sugen kinase 495 promotes the proliferation, migration and invasion of lung squamous cell carcinoma cells by targeting Foxo1 transcription factor.
Article Snippet: .. Figure legends AR TIC LE IN PR ES S Fig. 1 Sgk495 is highly expressed in LUSC and associated with poor prognosis. (A) Representative immunohistochemical images of Sgk495 protein expression in human lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) clinical tissue samples, obtained from the Human Protein Atlas (HPA) database. (B) Disease-free survival (DFS) analysis of LUSC patients from the TCGA database, stratified by high and low Sgk495 mRNA expression levels. ..

In Silico:

Article Title: TMBIM6 enhances dopaminergic neuron survival by modulating the IRE1a pathway in Parkinson’s disease
Article Snippet: .. Using data on TMBIM6 mRNA expression levels from The Human Protein Atlas database (THPA) [ ], we confirmed through in silico analysis that TMBIM6 is expressed in various cortical regions of the human brain, with notably high expression in the midbrain and retina, two areas rich in DAergic cells [ , ] (Fig. ). ..



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